Isotretinoin is an effective therapy for severe acne. It has the best influence on the health-related quality of life in acne patients Some side effects of isotretinoin are well known and predictable such as cheilitis and xerosis. Other side effects are known but less common such as hyperlipidemia. It is a known teratogenic medication and is contraindicated in pregnancy. Several other side effects are reported but less commonly. Depressive symptoms and suicidal ideation are other issues for the use of isotretinoin Vitiligo is an autoimmune disease of the skin and is thought to be of multifactorial causation Vitiligo patients have high prevalence of other autoimmune diseases. Thyroid function tests and thyroid autoantibodies might be used for screening for vitiligo patients. Here we report a case of vitiligo appearing after isotretinoin therapy. It is unknown whether this was a side effect of oral isotretinoin therapy or a coincidence.