The potential health benefits of green tea extract on the skin include: Protecting against ultraviolet radiation, improving wound healing, and cancer chemoprevention. An extract of C. sinensis was developed and tested chemically. The gene expression levels of selected enzymes in a human dermal fibroblast cell line treated with this phytoextract were determined. HAS-2, MMP-9 and elastase were studied. Gene expressions of the relevant enzymes and as control GAPDH were determined by RT-qPCR analysis. Green tea extract caused significant upregulation of HAS-2 gene expression (p<0.001).The treatment resulted in significant downregulation of MMP-9 (p=0.011) and elastase (p<0.001). Green tea extract was found to have substantial anabolic effects on HA, collagen and elastin. The results obtained by this study may partially explain the molecular basis of the anti aging health benefits of C. sinensis on the skin.